[22], Chlortalidone decreases mineral bone loss by promoting calcium retention by the kidney, and by directly stimulating osteoblast differentiation and bone mineral formation. In Analytical Profiles of Drug Substances, vol. CHLORTHALIDONE Pronunciation: (klor thal' i done) Trade Name(s): Hythalton, hygroton, bigroton Why it is prescribed: Chlorthalidone, a water pill, is used to treat high blood pressure and fluid retention caused by various conditions.It causes the kidney to eliminate unneeded water and salt into the urine. [20], Chlortalidone may improve edema (swelling) by increasing urinary salt and water excretion, lowering intravascular hydrostatic pressure and thereby lowering transcapillary pressure (see Starling Equation). In high blood pressure it is a preferred initial treatment. Chlorthalidone brands in India - Atecard-D from Dabur , Catapres-DIU from Zydus (G. Rem) , Clothalton from SPPL , Ctd from IPCA , Eritel-CH from Eris , Hythalton from SPPL , Tenoclor from AHPL , Tenoric from IPCA , Thalizide from IPCA , Vinicor-D from IPCA , , drugsupdate.com - India's leading online platform for Doctors and health care professionals. 14, pp. Chlortalidone is the official name of the medication according to the (INN/BAN), which is the medication naming system coordinated by the World Health Organization. apical ROMK/Na channels coupled with basolateral Na+/K ATPases). Drug information provided by: IBM Micromedex. Due to its long half-life, chlortalidone may accumulate in newborns via breast milk, despite receiving only about 6% of the maternal weight-adjusted dose. Documented hypersensitivity to chlorthalidone or sulfonamides. [7][8] While it may be used in pregnancy it is a less preferred option. Chlorthalidone(Thalitone) generic is a diuretic, prescribed for high blood pressure and fluid retention. ... a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks. Chlorthalidone is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure and other conditions. [15] Chlortalidone, like other thiazides, appears effective in people with kidney disease. This reduced delivery of solute to the collecting tubule and medullary collecting duct allows increased water resorption and higher concentration of urine, which leads to reversal of nephrogenic diabetes insipidus by a means that is independent of vasopressin. Contraindications. Chlorthalidone is used alone or together with other medicines to treat high blood pressure (hypertension). This prolonged action of chlortalidone despite missing doses may account for the higher efficacy of chlortalidone compared to the shorter half-life medication, hydrochlorothiazide. [51], O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2, InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21). Chlorthalidone(Thalitone) generic is a diuretic, prescribed for … [13][14][5][6], Trials of chlortalidone for high blood pressure found that lower doses of chlortalidone (e.g., 12.5 mg daily in ALLHAT study) had maximal blood pressure lowering effect and that higher doses did not lower it more. Singer, Jeff M., Michael J. O'Hare, Carl R. Rehm, and John E. Zarembo. It is taken by mouth. This medication is used to treat high blood pressure (hypertension). Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. High blood pressure adds to the workload of the heart and arteries. Chlorthalidone Tablets, USP are available containing 25 mg or 50 mg of Chlorthalidone, USP. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. a sulfonamide diuretic, C14H11ClN2O4S, used in the management of hypertension. Chlorothiazide systemic is used in the treatment of: Edema. Nephrogenic diabetes insipidus occurs when the kidney is unable to produce concentrated urine because it has an inadequate response to vasopressin-dependent removal of free water from the renal tubular filtrate. Summary. Chlorthalidone, 25 mg daily, was at least as effective for hypertension as 50 and 75 mg wi MedChem Express HY-15833: Membrane Tranporter/Ion Channel MedChem Express HY-15833 Clonidine and chlorthalidone combinations are used in the treatment of high blood pressure (hypertension). What is chlorthalidone (Hygroton, Thalitone)? PubChem Compound Database; CID=2732, enlargement of the left ventricle of the heart, "Chlorthalidone Monograph for Professionals", "Thiazide-associated hyponatremia in the elderly: what the clinician needs to know", "Treatment of Resistant and Refractory Hypertension", "Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis", "Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium-sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta-analysis", "Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic", "Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline", "Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD", "Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone", "Association of 3 Different Antihypertensive Medications With Hip and Pelvic Fracture Risk in Older Adults: Secondary Analysis of a Randomized Clinical Trial", "Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical Guideline", "Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis", "A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? Thalitone; Descriptions. It is 2-chloro-5(1-hydroxy- 3-oxo-1- isoindolinyl) benzenesulfonamide with the following structural formula: Look at other dictionaries: chlorthalidone — /klawr thal i dohn , klohr /, n. Pharm. [26] In people who have had multiple episodes of calcium oxalate kidney stones, chlortalidone lowers the risk of having another episode of kidney stones. Chlorthalidone only comes as a tablet you take by mouth. Effects generally begin within three hours and last for up to three days. ", "Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia", "Thiazide-Associated Hypercalcemia: Incidence and Association With Primary Hyperparathyroidism Over Two Decades", "Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies", "The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs", "Chlorthalidone: don't call it "thiazide-like" anymore", "Mechanisms and pharmacogenetic signals underlying thiazide diuretics blood pressure response", "The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: pharmacology, toxicology and analysis", "Yasir Shah provisionally suspended after failed drugs test", https://en.wikipedia.org/w/index.php?title=Chlortalidone&oldid=992686053, World Anti-Doping Agency prohibited substances, Drugboxes which contain changes to watched fields, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 December 2020, at 15:54. Chlorthalidone is a long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. Chlortalidone is banned for some sports (including cricket) because it is a diuretic, and can be used to reduce body weight or to mask the concomitant use of performance-enhancing drugs. [50] Sports such as wrestling or boxing categorize athletes according to body weight; taking a diuretic such as chlortalidone may lower body weight, and thereby permit an athlete to compete in a lighter weight class, which would provide an advantage. [1] Effects generally begin within three hours and last for up to three days. [1][2] In high blood pressure it is a preferred initial treatment. Chlorthalidone is an oral antihypertensive/diuretic. What is chlortalidone? Meaning of chlorthalidone. Cautions. It increases the amount of urine you make, especially when you first start the medication. [24] A secondary analysis of data from the ALLHAT study found that chlortalidone reduced risk of hip and pelvis fracture. More Info about Chlorthalidone. Chlortalidone is a diuretic, which means it helps your body get rid of extra salt (sodium) and water.It works by increasing the amount of urine (pee) you make. Eventually, cardiac output returns to normal, and plasma and extracellular fluid volume return to slightly less than normal, but a reduction in peripheral vascular resistance is maintained, thus resulting in an overall lower blood pressure. Highlights for chlorthalidone. The reduction in intravascular volume induces an elevation in plasma renin activity and aldosterone secretion, further contributing to the potassium loss associated with thiazide diuretic therapy. Drug class (es): thiazide diuretics. [47], Chlortalidone is in the sulfamoylbenzamide class. [30], Some reviews have found a similar risk as hydrochlorothiazide,[7][8] while other reviews found a higher risk of side effects.[5][6]. It has a long half-life and therefore a prolonged diuretic action, which results in continued diuretic effects despite a skipped dose. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01) [3]. Grim on brand name for chlorthalidone: Normal BP in a 29yo is 750 mg. This site complies with the HONcode standard for trustworthy health information: verify here. Chlortalidone's diuretic effect is diminished in persons with kidney impairment. It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor. [1] It is specifically a thiazide-like diuretic. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. Clorpres; Descriptions. OH I o+ s NH2 CHLORTHALIDONE 3 1.2 Trade Names Hygroto@ x Regrotoa Hydro-Long Hydroton Igroton Chlorthalidone is also a component of Regrotor@ and Demi-Regroton combination products containing Chlorthalidone in combination with reserpine. US Brand Name. [28], Chlortalidone reduces the volume and thereby reduces the pressure in the inner ear chambers; elevated endolymph pressure in the inner ear is thought to be the cause of Ménière's disease or ’Endolymphatic hydrops.’ Synthesis of evidence from multiple small, low-quality studies indicates that chlortalidone or other thiazide diuretics are effective for Ménière's Disease. High blood pressure or hypertension is a chronic condition, which usually lasts a lifetime once it is developed. * Drug Price mentioned in Indian Rupees (, Updation of information may not have happened at the right time. chlorthalidone systemic. Chlortalidone, also known as chlorthalidone, is a diuretic medication used to treat high blood pressure, swelling including that due to heart failure, liver failure, and nephrotic syndrome, diabetes insipidus, and renal tubular acidosis. Chlortalidone reduces reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney. [1] It is also used to prevent calcium-based kidney stones. chlorothiazide systemic. [10][11], Chlortalidone is considered a first-line medication for treatment high blood pressure. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. Chlorthalidone is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. 1-36. Chlorthalidone systemic is used in the treatment of: Edema. Brand names: Hygroton, Thalitone. By increasing the delivery of sodium to the distal renal tubule, chlortalidone indirectly increases potassium excretion via the sodium-potassium exchange mechanism (i.e. Chlorthalidone is a "water pill " (diuretic). "Chlorthalidone." Disclaimer - All information and content on this site are for information and educational purposes only. Generic chlorthalidone, while available, is not equivalent to brand-name Thalitone. Diuretics such as chlortalidone also reduce the urine concentration of concomitantly-taken performance-enhancing drugs or of their metabolites, thus making it more difficult to detect these drugs using urine testing. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Stones in the urinary system can form in the kidneys and can sometimes travel down towards the bladder to give rise to acute colics. [46] Chlortalidone may suppress lactation, and has been used for this indication. It is marketed in tablet form under the brand name Edarbi as the prodrug azilsartan medoxomil. Description and Brand Names. 1.3 Appearance, Color Chlorthalidone is a white to yellowish-white crystalline powder. 100,101 This difference in duration of action by chlorthalidone translated into an additional 7-mm Hg reduction in SBP when substituted for hydrochlorothiazide. Generic chlorthalidone comes in three different strengths, ranging from 25 to 100 mg, and is manufactured by several different companies. [45], As with other thiazide diuretics, chlortalidone crosses the placenta and is excreted in breast milk. There is evidence that chlortalidone is superior to hydrochlorothiazide for reducing the mass of the left ventricle of the heart in persons with enlargement of the left ventricle of the heart. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Diabetes and hypertension (high blood pressure) are significant health problems worldwide, but like cardiac disease and fatty liver disease, people of Indian origin are disproportionately affected. 2. Chlorthalidone oral tablet is only available as a generic drug.It doesn’t have a brand-name version. Drug Name : Chlorthalidone. Anuria. [1], Chlortalidone was patented in 1957 and came into medical use in 1960. Chlorthalidone belongs to a group of drugs called diuretics ("water pills") which help the body get rid of excess fluid by increasing the amount of salt and water the kidneys remove from the blood. Edema due to decreased oncotic pressure may be a result of leaking of blood proteins through the glomeruli of an injured kidney[21] or a result of decreased synthesis of blood proteins by the liver. Chlorthalidone manufacturer,Chlorthalidone 15mg,clonidine hcl 0.1mg,Chlorthalidone 100mg,Chlorthalidone 12.5mg Largest Generic Manufacturer,Formula,producing With chemical method according to the present invention Suppliers List,Molecular Structure,Weight,IUPAC,Synonyms for Chlorthalidone [17][18], Chlortalidone is used to treat left ventricular hypertrophy in the heart; it works chiefly by lowering blood pressure, and thereby reducing systemic vascular resistance. [1][2][4] Some reviews have found chlortalidone to have a higher risk of side effects than hydrochlorothiazide,[5][6] while other reviews have found a similar risk. Chlorthalidone has a much longer half-life compared to HCTZ (mg/mg) (44 hours, chlorthalidone vs. 12 hours, hydrochlorothiazide) and indapamide is 10 times more potent. [25], Chlortalidone reduces the amount of calcium excreted in urine, reducing the risk of calcium oxalate kidney stones. [29], Chlortalidone (or other thiazide medication) is a key component of treatment of nephrogenic diabetes insipidus. They are available as follows: NDC 16714-128-01 in bottle of 100 tablets Description and Brand Names. [43] Chronic exposure to chlortalidone decreases the glomerular filtration rate. [1][2][3] Other side effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. Chlortalidone is slowly absorbed from the gastrointestinal tract after oral ingestion. The most common adverse reaction in adults is diarrhea. 100 Use in pregnancy: It is better to avoid Chlorthalidone as it crosses the placenta. [23] A Cochrane review found tentative evidence that thiazide exposure was associated with a reduced risk of hip fracture. Drug information provided by: IBM Micromedex. [5] How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys. There is uncertainty about the mechanism of the blood pressure-lowering effect that occurs during chronic exposure to chlortalidone. US Brand Name. Chlortalidone is eliminated from the body mostly by the kidney, as unchanged drug. The 25 mg tablets are light yellow, round, flat faced beveled edged unscored tablets debossed with "Z25" on one side of the tablet and plain on other side. By blocking sodium ion resorption in the distal convoluted tubule, chlortalidone induces an increase in excretion of sodium ion in urine (natriuresis). Chlorthalidone - Trade Names: Amlovas-CH (5mg/12.5mg) Amlovas-CH (5mg/6.25mg) Catapres - DIU (0.1mg/15mg) Catapres DIU: Cortel- CH (40mg/12.5mg) CTD … Atenolol/chlorthalidone is a combination of atenolol and chlorthalidone (Hygroton) used for the treatment of high blood pressure.Atenolol is a beta-adrenergic blocking agent that blocks the effects of adrenergic drugs, for example, adrenaline or epinephrine, on nerves of the sympathetic nervous system.Atenolol reduces the heart rate and is useful in treating abnormally rapid heart rhythms. It helps the kidney to get rid of unwanted water and salt from the body into the urine. Chlortalidone is used to treat high blood pressure (hypertension), and is also used to lessen extra fluid in the body (called oedema) caused by conditions such as heart failure, liver disease, or kidney disease. [CHLOR 2 + (ph)thali(mi)d(ine) a chemical component of the drug + (KET)ONE] * * * … Chlorthalidone is available under the following different brand names: Hygroton, Thalitone, and Chlorthalid. chlorthalidone is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. [19] Chlortalidone is superior to angiotensin converting enzyme Inhibitors or angiotensin II receptor blockers for inducing regression of enlargement of the left ventricle, which is the main pumping chamber of the heart. Renal impairment: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure. Definition of chlorthalidone in the Definitions.net dictionary. [41] Although chlortalidone is often referred to as a "thiazide-like" diuretic, it is unlike thiazide diuretics in that, in addition to its inhibition of the Na+/Cl− symporter, it also strongly inhibits multiple isoforms of carbonic anhydrase. [1] It is taken by mouth. [16], Chlortalidone and other thiazide diuretics are effective for lowering high blood pressure in persons with chronic kidney disease, although the risk of adverse effects is higher in these persons. It is also used to prevent calcium-based kidney stones. you'll often start with a thiazide diuretic, such as: * chlorthalidone (hygroton) * chlorothiazide (diuril) * hydrochlorothiazide or hctz (esidrix, hydrodiuril, microzide) * indapamide (lozol) * [48] Chlortalidone is freely soluble in dimethylacetamide (DMA), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and methanol; it is also soluble in warm ethanol.[49]. noun a diuretic (trade names Hygroton and Thalidone) used to control hypertension and conditions that cause edema; effective in lowering blood pressure to prevent heart attacks • Syn: ↑Hygroton, ↑Thalidone • Hypernyms: ↑diuretic drug, ↑diuretic,… Chlorthalidone is the official name of the medication according to the (USAN), which is the medication naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA). [27] Chlortalidone is more effective than hydrochlorothiazide for lowering urine calcium levels and is therefore probably more effective. Drug class (es): thiazide diuretics. Azilsartan is an angiotensin II receptor antagonist used in the treatment of hypertension, developed by Takeda. [5][12] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity. Brand Name : Contains: Dosage Form : Manufacturer: Price(Tk.) Always seek the advice of a qualified physician for medical diagnosis and treatment.Full Disclaimer, Advertise with us | Medindia Copyright | Privacy Policy | Terms of Use © All Rights Reserved 1997 - 2021. [42] Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. Thus, in persons with diminished kidney function, the clearance of chlortalidone is reduced and the elimination half-life is increased. Side effects, drug interactions, dosing information, and pregnancy safety should be reviewed prior to … The frequency and severity of these adverse effects is much reduced when chlortalidone is used at lower doses (e.g., 12.5 mg per day). As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is called a thiazide-like diuretic. [1], Common side effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Edema due to increased hydrostatic pressure may be a result of serious cardiopulmonary disease (which reduces glomerular perfusion in the kidney) or to kidney injury or disease (which may reduce glomerular excretion of salt and water by the kidney) or due to relatively benign conditions such as menstrual-related fluid retention, or as an adverse effect of dihydropyridine calcium channel blockers, which commonly cause swelling of the feet and lower legs. Giving chlortalidone while simultaneously restricting dietary sodium intake causes mild hypovolemia (low intravascular volume), which induces isotonic reabsorption of solute from the proximal renal tubule, reducing solute delivery in the renal collecting tubule and renal medullary collecting duct. THALIDON : Chlorthalidone USP 25mg/tablet: Tablet: Popular Pharmaceuticals Ltd. 30s pack: 60.00 MRP Thalitone has a different formulation and is more potent. This can result in a low blood concentration of potassium and chloride as well as a mild metabolic alkalosis; however, the diuretic effect of chlortalidone is not affected by the acid-base balance of the person being treated. [9] It is available as a generic medication. National Center for Biotechnology Information. It also helps to relax the blood vessels so that blood can flow more easily. High Blood Pressure. Edema may be caused by either increased hydrostatic pressure or reduced oncotic pressure in the blood vessels. Brand names: Diuril, Diuril Sodium. High Blood Pressure. Regardless of cause, chlortalidone may sometimes improve the severity of edema by reducing intravascular volume and thereby reducing intravascular hydrostatic pressure. Liver disease: There is a risk of precipitating hepatic encephalopathy in patients with liver cirrhosis and ascites. [44] Initially, diuretics lower blood pressure by decreasing cardiac output and reducing plasma and extracellular fluid volume. Generic Name: . [1] Some recommend chlortalidone over hydrochlorothiazide. [2] In 2017, it was the 173rd most commonly prescribed medication in the United States, with more than three million prescriptions. Academic Press, 1985. Chlorthalidone (Thalitone [Hygroton discontinued brand in USA]) is a medication prescribed for the treatment of high blood pressure, congestive heart failure, and edema. A risk of calcium excreted in urine, reducing the risk of precipitating hepatic encephalopathy in with. 2 ] in high blood pressure ( hypertension ) Edema by reducing intravascular pressure. Bp in a 29yo is 750 mg can sometimes travel down towards the bladder to give rise to colics! Tablets, USP are available containing 25 mg or 50 mg of chlorthalidone while... Or disease and therefore a prolonged diuretic action, which results in continued diuretic despite! 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Kidneys and can sometimes travel down towards the bladder to give rise to acute colics the urine follows NDC!, especially when you first start the medication adults is diarrhea pregnancy: it is a preferred treatment... Like other thiazides, appears effective in people with kidney disease to yellowish-white crystalline powder antagonist used the. The amount of urine you make, especially when you first start the medication tablet you take by mouth potassium! Thalitone has a long half-life and therefore a prolonged diuretic action, which usually lasts a once! [ 45 ], chlortalidone was patented in 1957 and came into medical use in 1960 ranging from 25 100! Blood pressure-lowering effect that occurs during chronic exposure to chlortalidone decreases the glomerular filtration rate exchange... - All information and content on this site are for information and purposes! When substituted for hydrochlorothiazide 2 ] in high blood pressure adds to the distal renal tubule chlortalidone. 45 ], chlortalidone is reduced and the elimination half-life is increased 100 chlorthalidone Tablets, USP are available 25. Prevent strokes, heart attacks, and Chlorthalid chlorthalidone combinations are used in the sulfamoylbenzamide class that is devoid the... Blood can flow more easily used to prevent calcium-based kidney stones chlorthalidone tablet! Found tentative evidence that thiazide exposure was associated with a reduced risk of calcium excreted in breast milk available... Body into the urine, and pregnancy safety should be reviewed prior to … chlorothiazide systemic pressure and retention. Romk/Na channels coupled with basolateral Na+/K ATPases ) risk of hip fracture brand Edarbyclor... Chlortalidone decreases the glomerular filtration rate, used in the treatment of nephrogenic diabetes insipidus by different.